Application de reactions d'hydroalumination en synthese organique: obtention d'α-alkyl α-hydroxyesters par addition enantioselective de tetraalkylaluminates AU phenylglyoxalate de (−) menthyle. |
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| Authors: | G Boireau A Korenova A Deberly D Abenhaïm |
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| Institution: | Institut de Chimie Moléculaire d''Orsay Laboratoire de Chimie Organométallique, Université de Paris-Sud, Centre d''Orsay 91405 Orsay France |
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| Abstract: | Using tetraalkylaluminates prepared via hydroalumination in THF of various vinyl compounds resulted in selective addition to the keto group of phenylglyoxylic acid (?) menthyl ester. Not only simple alkyl groups but also functionalized alkyl groups were added. By this way, a variety of α-substituted mandelic acid (?) menthyl esters were obtained with diastereomeric excesses close to 70%. |
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| Keywords: | A qui la correspondance doit être adressée |
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