Oxidative transformation of tryptophan to 3-(2-aminophenyl)-2-pyrrolidone and kynurenine |
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Authors: | M. Nakagawa S. Kato H. Fukazawa Y. Hasegawa J. Miyazawa T. Hino |
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Affiliation: | Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Chiba-shi, 260, Japan |
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Abstract: | Oxytryptophans 3, which are readily obtained by dye-sensitized photooxygenation of tryptophan followed by acid treatment, undergo a facile N,N′-transacylation to give the 3-(2-aminophenyl)-2-pyrrolidones 4 in the absence of oxygen, whereas in the presence of oxygen 3a was oxidized to kynurenine. |
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