Vinyl radical cyclization in the synthesis of natural products: seychellene |
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| Authors: | Gilbert Stork Neil H. Baine |
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| Affiliation: | Department of Chemistry Columbia University New York, New York 10027 U.S.A. |
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| Abstract: | The use of vinyl radical cyclization in the simplification of synthesis design is probed with the sesquiterpene seychellene as a target. The construction is particularly effective because of very high stereoselectivity in the alkylation of a 2,2,2-bi- cyclo-5-octene-2-one system and because of the control offered by the specific location of the double bond in the product of the vinyl radical cyclization. |
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