Stereoselective annelation of trimethylsiloxyacetic acids and imines into 3-hydroxy- β-lactams

Stereoselective synthesis of variously substituted 3-hydroxy-β-lactams can be achieved by the annelation of Schiff bases with trimethylsiloxyacetic acids promoted by phenyl dichlorophosphate reagent. A potential synthesis of N-unsubstituted β-lactams is made.Although this investigation is still in its preliminary stages, the results obtained from the readily available hydroxyacetic acids suggest that the procedure herein described constitutes a useful and convenient strategy for the direct synthesis of 3-hydroxy-β-lactams and related compounds of biological interest such $\text{5a}$. We are continuing to study the scope of the method and we will report the results in due curse.