Reduction of bicyclo[3.2.0] hept-2-en-6-one and 7,7-dimethylbicyclo[3.2.0]hept-2-en-6-one using dehydrogenase enzymes and the fungus mortierella ramanniana期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Reduction of bicyclo[3.2.0] hept-2-en-6-one and 7,7-dimethylbicyclo[3.2.0]hept-2-en-6-one using dehydrogenase enzymes and the fungus mortierella ramanniana

Authors:	Suzanne Butt HGeoff Davies Michael J Dawson Gordon C Lawrence Jeff Leaver Stanley M Roberts Michael K Turner Basil J Wakefield Wilfred F Wall John A Winders

Institution:	1. Department of Microbiological Chemistry, Glaxo Group Research, Greenford, Middlesex, UB6 OHE, U.K.;2. Department of Medicinal Chemistry, Glaxo Group Research, Greenford, Middlesex, UB6 OHE, U.K.;3. Biotechnology Department, Glaxo Group Research, Greenford, Middlesex, UB6 OHE, U.K.;4. Department of Chemistry and Applied Chemistry, University of Salford, Salford, M5 4WT, U.K.

Abstract:	Bicyclo3.2.0]hept-2-en-6-one (1) was reduced with an alcohol dehydrogenase from $Thermoanaerobium brockii$ and a whole cell system ( $M. ramanniana$ ) with excellent substrate enantioselectivity: 7,7-dimethylbicyclo3.2.0]hept-2-en-6-one (2) was similarly reduced using the 3α,20β-hydroxysteroid dehydrogenase from Streptomyces $hydrogenans$ while $M. ramanniana$ furnished both 6S-alcohols (4a), (6b) with high optical purity.

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