A total synthesis of methylenomycin B |
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| Authors: | F Camps J Coll JM Moretó J Torras |
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| Institution: | Departament de Productes Orgànics Bioactius (C.S.I.C.) c/ Jorge Girona Salgado, 18-26, 08034-Barcelona, Spain. |
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| Abstract: | A new synthesis of methylenomycin B (1) has been accomplished in four steps starting with a NI(CO)4 promoted cyclocondensation reaction of allyl chloride and 2-butyn-1-ol in MeOH, followed by hydrogenolysis of the resulting mixture to 2,3-dimethyl-5-methyl-oxycarbonylmethyl-2-cyclopentenone (3), which by hydrolysis and oxidative decarboxylation yielded 1. |
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