Preparation of optically active 1-acetoxy-2-aryloxypropionitriles and its application to a facile synthesis of (S)-(−)-propranolol |
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| Authors: | Noritada Matsuo Nobuo Ohno |
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| Institution: | Pesticides Research Laboratory, Takarazuka Research Center, Sumitomo Chemical Co., Ltd., 4-2-1 Takatsukasa Takarazuka, Hyogo 665, Japan |
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| Abstract: | (S)-1-acetoxy-2-aryloxypropionitriles were synthesized by an asymmetric hydrolysis of the racemates with an enzyme. (S)-propranolol, a typical β-adrenergic blocker, was synthesized from (S)-1-acetoxy-2-α-naphthyloxypropionitrile in two steps. |
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