Oxyallyls in synthesis: Preparation of tricyclic thromboxane A2 analogues |
| |
| Authors: | Kevin G Bowers John Mann |
| |
| Institution: | Department of Chemistry, University of Reading, Whiteknights, P.O. Box 224, Reading, Berkshire, RG6 2AD U.K. |
| |
| Abstract: | We describe the formation of 1-(dimethoxymethyl)-2-(2-phenylethenyl)-8-oxabicyclo3.2.1]oct-6-en-3-ol (4) using oxyallyl methodology, and conversion of this into two 2,6-dioxatricyclo3.3.1.03,7] nonanes (9) and (10) via iodoetherification and reduction. These compounds were then elaborated into the novel thromboxane analogues (11) and (12). |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
