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The regioselective deprotonation of conjugated acids
Authors:Francis L. Harris  Larry Weiler
Affiliation:Department of Chemistry, California State University, Northridge, CA, 91330, U.S.A.;Department of Chemistry, University of British Columbia, Vancouver, B.C., V6T 1Y6, Canada
Abstract:A stereoselective synthesis of E and Z C-4 deuterated 3-methyl-2-butenoic acid from methyl acetoacetate is described; the labelled acids are regioselectively deprotonated syn to the acid function under kinetic conditions.
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