An asymmetric synthesis of α-tocopherol side chain |
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| Authors: | Kunihiko Takabe Yujiro Uchiyama Koichi Okisaka Takashi Yamada Takao Katagiri Tetuharu Okazaki Yoshiki Oketa Hidenori Kumobayashi Susumu Akutagawa |
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| Institution: | 1. R & D Institute, Takasago Perfumery Co. Ltd., 5-chome, Kamata, Ohta-ku, Tokyo 144, Japan |
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| Abstract: | A stereospecific synthesis of (3R,7R)?3,7,11-trimethyldodecanal (2) with highly optical purity was achieved by utilizing the coupling reaction of the amino sulfone (9) with(R)?3,7-dimethyloctyl magnesium bromide (7), and the asymmetric isomerization of the resulting(E)-allylic amine (10). |
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