Acid catalysis in aldol condensation of α-amino silyl ketene acetals. Diastereoselective synthesis of α-amino-β-hydroxyacids.期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Acid catalysis in aldol condensation of α-amino silyl ketene acetals. Diastereoselective synthesis of α-amino-β-hydroxyacids.

Authors:	Giuseppe Guanti Luca Banfi Enrica Narisano Carlo Scolastico

Affiliation:	(CNR - Centro di Studio sui Diariloidi e loro Applicazioni, Istituto di Chimica Organica dell''Università, Palazzo delle Scienze, Corso Europa, 16132 Genova Italy;(Istituto di Chimica Organica dell''Università, Via Venezian 21, 20133 Milano Italy

Abstract:	The aldol-type condensation between α-dibenzylamino trimethylsilyl ketene acetals and various achiral and chiral aldehydes in the presence of a Lewis acid furnishes α-amino-β -hydroxyacids in moderate yields with preferential C₂C₃ $threo$ configuration.

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