An effective method for removal of the internucleotidic phenylthio group from fully protected oligonucleotides by use of bis(tributyltin) oxide |
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| Authors: | Mitsuo Sekine Hiroshi Tanimura Tsujiaki Hata |
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| Affiliation: | Department of Life, Chemistry, Tokyo Institute of Technology, Nagatsuta, Midoriku, Yokohama 227, Japan |
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| Abstract: | Several kinds of organotin compounds involving stannyl oximates have been examined as reagents for deblocking the internucleotidic phenylthio group from an appropriately protected S-phenyl diuridine phosphorothioate (1). Among them, bis(tributyltin) oxide was found to be very effective. |
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