Goniothalenol: a novel,bioactive, tetrahydrofurano-2-pyrone from (annonaceae) |
| |
| Authors: | A.Atef Ebrabim El-Zayat Nelson R. Ferrigni Thomas G. McCloud Ann T. McKenzie Stephen R. Byrn John M. Cassady Ching-jer Chang Jerry L. McLaughlin |
| |
| Affiliation: | Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907 U.S.A. |
| |
| Abstract: | Fractionation of the stem bark of the title plant, monitoring for bioactivity with brine lethality, led to the isolation of goniothalenol (I). Mass, 1HNMR, and 13CNMR spectral data helped to characterized I as a phenyltetrahydrofurano-2-pyrone, as a novel heterocyclic ring system for natural compounds. X-Ray crystallographic analysis confirmed the structure and established the configuration for I. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
