Preparation of ethyl 5(s),6-epoxy-3(r)-(methoxymethoxy)hexanoate: a key chiral intermediate for mevinolin and compactin. |
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| Authors: | Yvan Guindon Christiane Yoakim Michael A. Bernstein Howard E. Morton |
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| Affiliation: | Merck Frosst Canada Inc., P.O. Box 1005, Pointe Claire-Dorval, Quebec, Canada H9R 4P8 |
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| Abstract: | The synthesis of Ethyl 5(S),6-Epoxy-3(R)-(methoxymethoxy)hexanoate, a key chiral synthon for the β-hydroxy-δ-lactone portion of Mevinolin and Compactin, a regiospecific ring opening of a tetrahydrofuran derivative by dimethylboron bromide, is described. |
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