Aziridines N-Non substituées. Détermination des Paramètres Thermodynamiques ΔG°, ΔH°, ΔS° Liés à l'Equilibre Conformationnel à partir de Mesures RMN 1H à Haut Champ

Although nitrogen inversion in unsubstituted aziridines has been shown by ¹H NMR, it was only possible to study quantitatively the distribution of both invertomers and determine the thermodynamic parameters by a systematic high field NMR study (CAMECA 250 MHz). Thermodynamic parameters have been determined for 32 compounds. In C-aryl aziridines, the steric hindrance of the aromatic group and its variation with other aziridine ring substituents can be studied. These observations are in agreement with a conjugation phenomenon between the aromatic system and the aziridine ring.