Synthesis of hexaphenylbenzene-based template assembled synthetic proteins |
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| Affiliation: | 1. Division of Organic Chemistry, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India;2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, India;3. Center for Material Characterization, National Chemical Laboratory, Pune, India;1. School of Sciences, QiLu University of Technology, Jinan 250353, P.R. China;2. State Key Laboratory for High-Field Laser Physics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, P.R. China;3. Department of Physics, Zhejiang Sci-Tech University, Hangzhou 310018, P.R. China;1. Dipartimento di Scienze Chimiche and I.N.S.T.M. UdR of Catania, Università di Catania, Viale A. Doria, 6, 95125 Catania, Italy;2. Istituto per la Chimica e la Tecnologia dei Polimeri (ICTP – CNR), Via Paolo Gaifami, 18, 95126 Catania, Italy;3. Istituto per i Processi Chimico Fisici (IPCF – CNR), Viale Ferdinando Stagno D’Alcontres, 37, 98158 Messina, Italy;1. Institute of Medical Mission, Department of Tropical Medicine, 97074 Würzburg, Germany;2. Laboratory of Molecular Physiology, Institute of Experimental Medicine, School of Medicine Luis Razetti, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Venezuela;3. Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany |
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| Abstract: | Template-assembled synthetic proteins (TASPs) synthesized from rigid templates have attracted attention due to their interesting structural architectures and potential biomedical applications. Herein, we report the design, synthesis and characterizations of TASPs based on hexaphenylbenzene template (HPB) having twelve peptide attachable axial-arms in its structure. The peptides were attached to all the axial-arms of the template in a single step using simple solution phase peptide coupling strategy. The reaction conditions were standardized systematically using simple amines from smaller size to larger ones. |
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| Keywords: | TASP Hexaphenylbenzene Peptides Proteins |
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