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An efficient and robust synthesis of amorfrutin A
Affiliation:1. International Joint Research Laboratory of Nano-Micro Architecture Chemistry, Institute of Theoretical Chemistry, Jilin University, Changchun 130023, China;2. Department of Chemical Technology, Jilin Institute of Chemical Technology, Jilin 132022, China;3. School of Opto-Electronic Information Science and Technology, Yantai University, Shandong 264005, China;4. College of Science, Hunan Agricultural University, Changsha 410128, China;5. Department of Nano-Physics, Gachon University, Gyeonggi 13120, Republic of Korea;1. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China;2. Institute of Modern Chinese Herbal of Guizhou Academy of Agricultural Sciences, Guiyang 550006, PR China;3. TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, PR China;1. CSIR-Medicinal Chemistry Division, Indian Institute of Integrative Medicine, Sanatnagar-Srinagar 190005, India;2. Academy of Scientific & Innovative Research (AcSIR), India;3. School of Chemistry, University of Hyderabad, Hyderabad 500046, India;1. School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China;2. Yunnan Research Institute of Tobacco Science, Kunming 650106, China;3. School of Pharmacy, Kunming Medical University, Kunming 650500, China;1. Department of Chemistry, Ravenshaw University, Cuttack, Odisha, India;2. Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India;3. School of Chemical Sciences, National Institute of Science Education and Research, Bhubaneswar, Odisha 751 005, India
Abstract:Amorfrutin A was synthesized via a short sequence in an overall yield of 41% using a green, aerobic oxidation/re-arrangement process as the key-step.
Keywords:Amorfrutin A  Hydroperoxide  Aerobic oxidation
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