Synthetic approaches to the daphnane and tigliane diterpenes from aromatic precursors |
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| Affiliation: | 1. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China;3. Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650204, PR China |
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| Abstract: | Synthetic studies toward the daphnane and tigliane diterpenes, a large family of natural products from the plant families Euphorbiaceae and Thymelaeaceae, are reported. Retrosynthetic analysis traced these molecules back to an aromatic precursor and several routes were explored in the forward direction to access such motifs. Two strategies ultimately proved capable of forging complex 5,7,6-fused tricyclic ring systems, one of which proceeded in only seven steps. |
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| Keywords: | Terpene Total synthesis Natural product Cascade reaction |
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