KOH/DMSO: A basic suspension for transition metal-free Tandem synthesis of 2,3-dihydroquinazolin-4(1H)-ones |
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| Institution: | 1. Department of Chemistry, Dibrugarh University, Dibrugarh 786004, Assam, India;2. AcSIR, Salt and Marine Chemicals Division, CSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar 364002, India;3. Nano Catalysis, Catalytic Conversion and Process Division, CSIR-Indian Institute of Petroleum, Mohkampur, Dehradun 248005, India;1. Department of Chemistry, Dibrugarh University, Dibrugarh-786004, Assam, India;2. Center for Materials for Electronics Technology, Pashan Road, Pune 411008, India;3. Defence Research Laboratory, Tezpur 784001, Assam, India;1. Henan Key Laboratory of Polyoxometalate Chemistry, Institute of Molecular and Crystal Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, China;2. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian National Laboratory for Clean Energy, Dalian 116023, China;1. Chemical Engineering College, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing, Jiangsu, People''s Republic of China;2. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, People''s Republic of China;1. Department of Chemistry, School of Sciences, Tianjin University, Tianjin, 300072, PR China;2. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, 300072, PR China |
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| Abstract: | A novel protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones from 2-aminobenzamides and aldehyde derivatives catalyzed by KOH/DMSO suspension has been developed. The present transition metal free methodology is operationally simple, scalable and varieties of 2,3-dihydroquinazolin-4(1H)-one derivatives were obtained in good to excellent yields in short reaction times. |
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| Keywords: | Base Metal free Scalable Tandem synthesis |
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