乏氧光学影像探针的设计与应用

氧气在生命活动中具有重要意义, 为需氧生物提供了重要的能量来源, 氧气供应不足会导致组织乏氧. 乏氧往往与炎症、 慢性伤口及肿瘤等多种疾病密切相关, 而组织氧浓度是评估机体健康的重要依据. 光学成像在空间分辨率、 灵敏性和成本方面的巨大优势使其成为炎症、 癌症、 脑部疾病和手术导航的重要影像诊断工具. 本文介绍了数种乏氧响应的光学探针的合成策略, 并展示了不同的乏氧光学探针在肿瘤检测、 炎症监测、 伤口氧含量监测、 治疗响应监测和食品包装检测等方面的应用, 最后探讨了乏氧光学成像的应用前景.

Design and Applications of Hypoxia Optical Probes

Oxygen plays an important role in life activities and provides an important source of energy for aerobic organisms. Insufficient oxygen supply will lead to tissue hypoxia. Hypoxia is often closely related to inflammation， chronic wounds， tumors and other diseases， and tissue oxygen concentration is also an important basis for evaluating body health. The enormous advantages of optical imaging in terms of spatial resolution， sensitivity and cost-effectiveness make it an important imaging diagnostic tool for inflammation， cancer， brain diseases， and surgical navigation. In this review， we introduce the synthesis strategies of several hypoxia-responsive optical probes and illustrate the applications of different hypoxia optical probes in tumor detection， inflammation monitoring， wound oxygen content imaging， treatment response monitoring and food packaging. Finally， we discussed the application prospect of hypoxia optical imaging.