Thalicfoetine,a novel isoquinoline alkaloid with antibacterial activity from Thalictrum foetidum |
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| Institution: | 1. Chemistry Division, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata – 700032, India;2. Molecular Parasitology Laboratory, Infectious Diseases & Immunology Division, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata – 700032, India;3. Chemistry Division, Sir Padampat Singhania University, Udaipur, Rajasthan, India;4. Department of Pharmaceutical Technology, Jadavpur University, Kolkata – 700032, India |
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| Abstract: | Thalicfoetine (1), the first O-bridged spirobenzylisoquinoline alkaloid possesses a spiro tetrahydropyridine-furanone core, was isolated from the roots of Thalictrum foetidum. Its structure was elucidated by extensive spectroscopic analyses and ECD calculation. Moreover, 1 exhibited antibacterial activity against Bacillus subtilis significantly with MIC value of 3.12 μg/mL. |
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| Keywords: | Benzylisoquinoline alkaloid Thalicfoetine Antimicrobial activity |
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