一步法高通量可控制备生物相容水/水微囊及其响应释放

生物相容水/水微囊在药物递送、 医学治疗等领域具有重要应用. 本文通过设计同轴微流控器件, 结合数值模拟优化和流动阻力分析, 实现一步法高通量可控制备大小均匀、 尺寸可控、 壁厚可调、 生物相容的水/水微囊. 采用实验研究和数值模拟相结合的方式, 研究了微流控器件结构、 内相流速、 外相流速、 外相/空气界面张力、 内相/外相界面张力、 内相黏度和外相黏度等参数对水/水微囊直径和壁厚的调控规律. 通过微通道流动阻力分析, 设计多通道平行放大微流控器件, 实现尺寸均匀可控水/水微囊的高通量制备. 验证了生物相容水/水微囊作为活性物质的理想载体, 可以通过改变pH或溶解囊壁释放载体, 进而实现活性物质的pH响应释放, 为其实际应用奠定了基础.

One-step High-throughput Controlled Preparation of Biocompatible Water/Water Microcapsules with Triggered Release

Biocompatible water/water microcapsules are of great significance for drug delivery and medical therapy. In this paper， co-axial microfluidic devices were designed via the optimization by numerical simulations and the analysis of flow resistance to realize one-step high-throughput controlled preparation of water/water microcapsules with good uniformity， tunable size and shell thickness， and excellent biocompatibility. Specifically， the influences of device design， inner phase flow rate， outer phase flow rate， outer phase/air interfacial tension， inner phase/outer phase interfacial tension， inner phase viscosity and outer phase viscosity on the diameter and shell thickness of water/water microcapsules were systematically investigated by means of experiments and simulations. By carefully analyzing the flow resistance of microchannels， microfluidic devices were parallelly amplified to achieve high-throughput preparation of water/water microcapsules with controlled size. Biocompatible water/water microcapsules are ideal delivery vehicles for various actives， showing controlled pH-triggered release of encapsulated cargos， which pave the way for their practical applications.