手性金属有机笼MOC-PA作为毛细管电泳手性固定相

报道了一种手性金属有机笼[Cu₁₂(L_PA)₁₂(H₂O)₁₂]（PA=L-苯丙氨酸, MOC-PA)作为毛细管电泳分离新型固定相的研究. 采用X射线粉末衍射仪、 红外光谱、 热重分析和扫描电子显微镜对该材料进行了表征, 结果表明该手性金属有机笼具有良好的热稳定性和空间结构. 利用该材料制备的毛细管色谱柱具有良好的手性识别能力, 可拆分1,2-二苯基乙二醇、 佐匹克隆、 4-甲基二苯基甲醇和茴香偶姻等手性药物, 也能拆分位置异构体硝基苯酚. 通过对拆分1,2-二苯基乙二醇、 佐匹克隆、 4-甲基二苯基甲醇和茴香偶姻进行最佳条件的探究, 得出电压、 缓冲溶液浓度及pH值在毛细管电泳中对手性样品分离度的影响. 采用佐匹克隆进行毛细管柱的重现性研究表明, 用该材料制备的毛细管电泳色谱柱具有一定的稳定性和重现性. 可见, 金属有机笼是一种良好的毛细管电泳手性固定相, 有一定的手性拆分能力, 在色谱分离中有较好的发展前景.

Chiral Metal-organic Cage MOC-PA as a Chiral Stationary Phase for Capillary Electrophoresis

A chiral metal-organic cage， ［Cu₁₂（L_PA）₁₂（H₂O）₁₂］（PA=L-phenylalanine， MOC-PA）， was used as a novel stationary phase for capillary electrophoresis separation. The material was characterized by X-ray powder diffractometer， infrared spectroscopy， thermogravimetric analysis and scanning electron microscope. The results showed that the chiral metal-organic cage has good thermal stability and spatial structure. The capillary chromatographic column prepared from this material has a good chiral recognition ability， which can resolve 1，2-diphenylethylene glycol， zopiclone， 4-methyldiphenyl methanol and anisin， as well as nitrophenol. By exploring the optimal conditions for 1，2-diphenylethylene glycol， zopiclone， 4-methyldiphenylcarbinol and anisoin， the effects of voltage， buffer solution concentration and pH on the resolution of chiral samples in capillary electrophoresis were obtained. And the reprodu?cibility study of the capillary column with zopiclone shows that the capillary electrophoresis column prepared from this material has specific stability and reproducibility. Therefore， the metal organic cage is a good chiral stationary phase in capillary electrophoresis， and has certain chiral separation ability and outstanding development prospect in chromatographic separation.