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Ni/NHC-catalyzed cross-coupling of methyl sulfinates and amines for direct access to sulfinamides
Institution:1. School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong, China;2. Qinghai Provincial Key Laboratory of Tibetan Medicine Research and Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, 810008 Qinghai, China;3. School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114, China;1. Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52056 Aachen, Germany;2. Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstraße 30, D-52074 Aachen, Germany;3. Department of Oncology, Hematology and Stem Cell Transplantation, Medical School, RWTH Aachen University, Pauwelsstraße 30, D-52074 Aachen, Germany;4. IAS-5/INM-9: Computational Biomedicine – Institute for Advanced Simulation (IAS)/Institute of Neuroscience and Medicine (INM) and Jülich Supercomputing Centre (JSC), Forschungszentrum Jülich, D-52425 Jülich, Germany
Abstract:It was reported to develop a simple and convenient method for the Ni/NHC-catalyzed cross-coupling of methyl sulfinates and amines without an acid/base to afford secondary or tertiary sulfinamides in moderate to good yields. The method can provide the desired products with broad substrate scope, good chemoselectivity and good functional group compatibility. The presented approach may enrich the Ni/NHC catalyst system and promote the applications of methyl sulfinates in the organic sulfur chemistry.
Keywords:Sulfinamide  Ni/NHC  Cross-coupling  Methyl sulfinates
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