Nickel catalyzed decarboxylative alkylation of aryl triflates with anhydrides |
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| Affiliation: | 1. Department of Chemistry, National University of Singapore, 4 Science Drive 2, 117544 Singapore, Republic of Singapore;1. School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China;2. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China;3. University of Chinese Academy of Science, Beijing 100049, China;1. Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323, USA;1. Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an 710127, China;2. Department of Chemistry, McGill University, Montreal, QB H3A 0B8, Canada;1. School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua- Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China;2. Advanced Innovation Center for Human Brain Protection, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100088, China;3. GNF/Novartis Institutes for BioMedical Research, San Diego, CA, 92122, USA;1. Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering, State Key Laboratory of Material-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, Jiangsu 211816, People’s Republic of China |
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| Abstract: | Aliphatic acid anhydrides are the versatile building blocks and the new method for the conversion of anhydrides is thus of great significance. Herein, we report the decarboxylative alkylation of aryl triflates with aliphatic acid anhydrides via nickel catalysis. This novel method provides a facile access to construct Csp2-Csp3 bond. In addition, this method is compatible with a broad array of functional groups and exhibits good substrates scope. |
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| Keywords: | Nickel catalysis Decarboxylative Aliphatic acid anhydrides |
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