AlCl3-promoted three-component cascade reaction for rapid access to [1,2,3]triazolo[5,1-a]isoquinolines |
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| Institution: | 1. CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India;2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, India |
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| Abstract: | Novel AlCl3-promoted, three component cascade Henry reaction-triazole formation-intramolecular 6-endo-dig cyclization reactions between 2-alkynylaryl aldehydes, nitroalkanes, and sodium azide for the assembly of 1,2,3]triazolo5,1-a]isoquinolines have been developed. Further transformations of representative 1,2,3]triazolo5,1-a]isoquinolines are also described. |
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| Keywords: | Cascade reaction Henry reaction Triazole |
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