Polyketides and nitrogenous metabolites from the endophytic fungus Phomopsis sp. D15a2a |
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| Institution: | 1. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany;2. Institute of Inorganic and Structural Chemistry, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany;3. Institute of Physiological Chemistry, Universitätsmedizin der Johannes-Gutenberg-Universität Mainz, 55128 Mainz, Germany;4. Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, Awka, Nigeria;5. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;1. College of Chemistry and Chemical Engineering, Xinjiang Normal University, Urumqi 830054, China;2. College of Life Science, Jiangxi Normal University, Nanchang 330022, China;1. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;2. Medical Science Research and Innovation Institute, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;3. Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;4. National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand;5. School of Science, Walailak University, Thasala, Nakhonsithammarat 80161, Thailand;6. Department of Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand;1. School of Pharmaceutical Sciences, Jinzhou Medical University, Jinzhou 121001, China;2. The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China;3. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China;1. The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate, 020-8550, Japan;2. Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, 997-8555, Japan;3. Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Gadjah Mada, Bulaksumur, Yogyakarta, 55281, Indonesia;4. Division of Dental Pharmacology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata, 951-8514, Japan |
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| Abstract: | Three new polyketides, phomopones A?C (1–3), one new cyclic tetrapeptide, 18-hydroxydihydrotentoxin (4), and a new amide, 6-hydroxyenamidin (5) together with a known derivative, enamindin (6) were obtained from the endophytic fungus Phomopsis sp. D15a2a isolated from the plant Alternanthera bettzickiana. The structures of the new compounds were elucidated by 1D, 2D NMR and HRMS data. The absolute configurations of the isolated metabolites were determined either by X-ray crystallography, Marfey’s method or by converting the compounds to Mosher esters. |
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| Keywords: | Endophytic fungus Polyketide Peptide |
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