Cytochalasins D1 and C1, unique cytochalasans from endophytic fungus Xylaria cf. curta |
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| Institution: | 1. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, Hubei 430074, PR China;2. National Demonstration Center for Experimental Ethnopharmacology Education (South-Central University for Nationalities), PR China;1. Key Laboratory of Marine Biogenetic Resources, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005, China;2. Yanjing Medical College, Capital Medical University, 4 Dadong Road, Beijing, 101300, China;1. College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea;2. College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea;3. Department of Food Science and Nutrition, Pukyong National University, Busan 608-737, Republic of Korea;1. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany;2. Institute of Inorganic and Structural Chemistry, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany;3. Institute of Physiological Chemistry, Universitätsmedizin der Johannes-Gutenberg-Universität Mainz, 55128 Mainz, Germany;4. Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, Awka, Nigeria;5. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China |
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| Abstract: | Cytochalasins D1 (1) and C1 (2) were isolated from the liquid fermentation of fungus Xylaria cf. curta. Their structures and absolute configurations were determined by comprehensive experimental spectroscopic methods as well as ECD and GIAO 13C NMR calculation. They possess a unique eleven-membered macrocycle with an oxygen bridge. Cytochalasins D1 and C1 showed moderate cytotoxicity against human leukemia cell lines HL-60 with IC50 value of 12.7 and 22.3 μM, respectively. |
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| Keywords: | Cytochalasans Structural elucidation Cytotoxicity |
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