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Synthesis of diverse libraries of carboxamides via chemoselective N-acylation of amines by carboxylic acids employing Brønsted acidic IL [BMIM(SO3H)][OTf] |
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| Institution: | 1. Department of Physics, Government First Grade College, Hubballi-580032, Karnataka, India;2. UG and PG Department of Physics, Karnataka Science College, Dharwad-580001, Karnataka, India;3. Department of Chemistry, Karnataka Science College, Dharwad-580001, Karnataka, India;4. P.G. Department of Chemistry, K.L. E. Society''s P. C. Jabin Science College, Hubli-580031, Karnataka, India;1. Department of Studies in Physics, Karnatak University, Dharwad 580 003, Karnataka, India;2. P. G. Department of Studies in Chemistry, K. L. E. Society''s P. C. Jabin Science College, Hubli 580 031, Karnataka, India |
| Abstract: | Chemoselective N-acylation of amines with carboxylic acids as acyl electrophiles and Brønsted acidic IL BMIM(SO3H)]OTf] as promoter is reported under both thermal and microwave irradiation to produce libraries of carboxamides in good to excellent yields after a simple workup. The protocol is compatible with structurally diverse 1° and 2° amines and works in the presence of sensitive functional groups such as thiols and phenols. The potential for recycling and reuse of the IL is also demonstrated. |
| Keywords: | Amines Carboxylic acids Microwave |
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