A simple synthesis of ketone from carboxylic acid using tosyl chloride as an activator |
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| Affiliation: | 1. Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China;2. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore;1. Anhui Key Laboratory of Energetic Materials, Huaibei Normal University, Huaibei 235000, China;2. Department of Material and Chemical Engineering, Zhengzhou Institute of Light Industry, Zhengzhou 450002, China;3. Department of Chemistry, Guangdong University of Education, Guangzhou 510303, China;1. Department of Organic Chemistry, Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City 70000, Viet Nam;2. Department of Magnetic and Biomedical Materials, Faculty of Materials Science, University of Science, Vietnam National University, Ho Chi Minh City 70000, Viet Nam |
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| Abstract: | An effective process for the conversion of carboxylic acid to ketone has been discovered. In this process, carboxylic acid has been activated using p-toluene sulphonyl group. Under the optimized condition, aromatic, aliphatic heteroaromatic carboxylic acids have been proved to be good substrates for this methodology. The byproduct of this reaction can be removed very easily during work up process. Also, one equivalent of organometallic reagent is sufficient to complete this transformation. |
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| Keywords: | Carboxylic acid Ketone Tosyl chloride Organometallic reagent |
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