A modified Pudovik reaction,self-catalysis synthesis of 3-phosphinoylindoles |
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| Institution: | 1. Department of Chemistry, Yogi Vemana University, Kadapa, AP 516003, India;2. Nano Catalysis and Solar Fuels Research Laboratory, Department of Material Science and Nanotechnology, Yogi Vemana University, Kadapa, AP 516003, India;1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmans’ka str., Kyiv 02660, Ukraine;2. Department of Organic Chemistry, National Technical University of Ukraine “Kyiv Polytechnic Institute”, 37, Prospect Peremogy, Kyiv 03056, Ukraine;1. Department of Pharmaceutical & Biological Engineering, School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, China;2. Natural Products Research Center Chengdu Institution of Biology Chinese Academy of Science, Chengdu, Sichuan 610041, China |
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| Abstract: | A new method for the synthesis of organophosphorus compounds between 3-hydroxy-3-indolyloxindoles and phosphite is described here. A modified Pudovik reaction is an efficient way applied in this approach. To be specific, this reaction proceeds smoothly under mild conditions with a self-catalysis system, diversely substituted α-functionalized phosphates are afforded with quaternary stereocenters in high yield, and the reaction time is acceptable due to the high reactivity. |
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| Keywords: | 3-Hydroxy-3-indolyloxindole Pudovik reaction α-Functionalized phosphates Diethyl phosphite |
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