DIPEA catalyzed step-by-step synthesis and photophysical properties of thieno[2,3-b]pyridine derivatives |
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| Affiliation: | 1. Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, Private Bag X06, Florida 1710, South Africa;2. Department of Life & Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Private Bag X06, Florida 1710, South Africa;1. Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210, Shanghai, China;2. School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China;3. Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031, Shanghai, China;4. University of Chinese Academy of Sciences, 100049, Beijing, China;5. Department of Chemistry, Scripps Research Institute, La Jolla, CA, 92037, USA;1. Ulyanov Chuvash State University, Cheboksary, Moskovsky pr., 15, Russia;2. Lomonosov Moscow State University, Moscow, Leninskie gori, 1, Russia;1. Wuxi School of Medicine, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China;2. CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;3. School of Pharmacy, China Pharmaceutical University, Jiangsu, Nanjing 210009, China;4. Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;5. State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China |
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| Abstract: | A series of novel 5,6-disubstituted ethyl 3-amino-4-cyanothieno[2,3-b]pyridine-2-carboxylates was synthesized. The reaction conditions were thoroughly studied and intermediate ethyl 2-((3,4-dicyanopyridin-2-yl)thio)acetates were successfully isolated in good yields. For all synthesized compounds, spectral-fluorescent properties were carefully investigated and correlation thereof with chemical structure was found. |
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| Keywords: | Pyridine Nitriles DIPEA Fluorescence |
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