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Development of 68Ga ethyl cysteinate dimer for PET studies |
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| Authors: | Alireza Mirzaei Amir R Jalilian Gholamali Shabani Ashraf Fakhari Mehdi Akhlaghi Davood Beiki |
| Institution: | 1. Nuclear Science and Technology Research Institute, 141551339, Tehran, Iran 2. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran 3. Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran |
| Abstract: | In this work development of 68Ga-ethyl cysteinate dimer (68Ga-ECD) a 68Ga tracer for possible cerebral blood flow based on 99mTc ECD homolog is reported. 68Ga-ECD was prepared using generator-based 68GaCl3 and ECD at optimized conditions. Quality control, stability, partition co-efficient and the biodistribution of the tracer (by tissue counting and PET/CT in rats) was studied. Significant metabolism of the lipophilic tracer into water soluble metabolite(s) led to urinary excretion of the tracer, un-comparable to that of homologous 99mTc-compound. Cardiac uptake of the complex suggests formation of a possible lipophil cationic complex and/or metabolite. |
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