|
|||||
|
|
Spectroscopic investigation of β-cyclodextrin -metoprolol tartrate inclusion complexes |
|
| Authors: | Felicia Dragan I Bratu Gh Borodi Mihaela Toma A Hernanz S Simon Gh Cristea R Peschar |
| Institution: | (1) Faculty of Pharmacy, University of Oradea, 1 Armatei Romane st, Oradea, Romania;(2) National R&D Institute of Isotopic and Molecular Technologies, P.O. Box 700, 400293 Cluj-Napoca 5, Romania;(3) Dep. CCTT Físicoquimicas, UNED Madrid, Senda del Rey 9, 28040 Madrid, Spain;(4) Faculty of Physics, ’Babes-Bolyai’ University, 1 Kogalniceanu st, Cluj-Napoca, Romania;(5) Laboratory for Crystallography, Universiteit van Amsterdam, Van ‘t Hoff Institute for Molecular Sciences, Valckenierstraat 65, 1018XE Amsterdam, The Netherlands |
| Abstract: | Aqueous-solution complexes of β-cyclodextrin (β-CD) with metoprolol tartrate (MET) have been analysed with 1H NMR and UV–vis spectroscopy. With 1H NMR a 1:1] stoichiometry could be established for the β-CD-MET complex while its stability constant was determined with UV–vis spectroscopy. Powder diffraction data of a polycrystalline sample of the β-CD-MET complex show that a novel product has been formed, likely to be a β-CD-MET 1:1] inclusion complex. Also Hyperchem MM+ molecular-dynamics results suggest an inclusion complex and from 1H NMR data it is inferred that probably the MET is docked in the CD with the formers methoxyethyl-benzene moiety in front. Mihaela Toma is Socrates/Erasmus student at UNED Madrid |
| Keywords: | Inclusion complexes Cyclodextrin Metoprolol Cardiovascular adrenoreceptor antagonist Powder diffraction NMR UV– vis Stoichiometry Stability constant |
| 本文献已被 SpringerLink 等数据库收录！ | |