Voltage-gated sodium channels in taste bud cells |
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Authors: | Na Gao Min Lu Fernando Echeverri Bianca Laita Dalia Kalabat Mark E Williams Peter Hevezi Albert Zlotnik and Bryan D Moyer |
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Institution: | (1) Senomyx, Inc, 4767 Nexus Centre Drive, 92121 San Diego, CA, USA;(2) Department of Physiology and Biophysics, University of California Irvine, 92697 Irvine, California, USA |
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Abstract: | Background Taste bud cells transmit information regarding the contents of food from taste receptors embedded in apical microvilli to
gustatory nerve fibers innervating basolateral membranes. In particular, taste cells depolarize, activate voltage-gated sodium
channels, and fire action potentials in response to tastants. Initial cell depolarization is attributable to sodium influx
through TRPM5 in sweet, bitter, and umami cells and an undetermined cation influx through an ion channel in sour cells expressing
PKD2L1, a candidate sour taste receptor. The molecular identity of the voltage-gated sodium channels that sense depolarizing
signals and subsequently initiate action potentials coding taste information to gustatory nerve fibers is unknown. |
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