| 溴乙酸叔丁酯的简便合成法 |
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| 引用本文： | 万福贤,韦继超,魏方方. 溴乙酸叔丁酯的简便合成法[J]. 化学研究, 2008, 19(4): 41-43 |
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| 作者姓名： | 万福贤 韦继超 魏方方 |
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| 作者单位： | 山东农业大学,化学与材料科学学院,山东,泰安,271018;山东农业大学,化学与材料科学学院,山东,泰安,271018;山东农业大学,化学与材料科学学院,山东,泰安,271018 |
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| 基金项目： | 国家自然科学基金 ， 泰安市大学生科技创新计划 |
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| 摘 要： | 首先以溴乙酸与氯化亚砜反应制备并分离得到溴乙酰氯，然后使其与叔丁醇在常温下反应合成溴乙酸叔丁酯．重点研究了影响酯化反应的因素，确定了酯化反应的最佳条件：三聚磷酸钠为缚酸剂，氯仿为溶剂，溴乙酰氯与叔丁醇的物质的量比1：1．15，收率93．6％．
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| 关 键 词： | 溴乙酰氯 溴乙酸叔丁酯 酯化 叔丁醇 三聚磷酸钠 |
A Simple Method for the Synthesis of tert-Butyl 2-Bromoacetate |
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| WAN Fu-xian,WEI Ji-chao,WEI Fang-fang. A Simple Method for the Synthesis of tert-Butyl 2-Bromoacetate[J]. Chemical Research, 2008, 19(4): 41-43 |
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| Authors: | WAN Fu-xian WEI Ji-chao WEI Fang-fang |
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| Affiliation: | (College of Chemistry and Materials, Shandong Agricultural University, Taian 271018, Shandong, China) |
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| Abstract: | At first,2-bromoacetyl chloride was prepared by the reaction of bromoacetic acid and thionyl chloride.Secondly,tert-butyl 2-bromoacetate was synthesized by the reaction of 2-bromoacetyl chloride with tert-butanol at room temperature.The factors effecting the reaction were investigated and the optimum synthetic conditions were determined as follows:stoichiometric sodium tripolyphosphate was used as catalysts and tie-acid agents,chloroform as solvent,molar ratio of 2-bromoacetyl chloride to tert-butanol was 1:1.15,and the yield was 93.6 %. |
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| Keywords: | 2-bromoacetyl chloride tert-butyl 2-bromoacetate esterification tert-butyl alcohol sodium tripolyphosphate |
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