Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zurich, Wolfgang‐Pauli‐Strasse 10, 8093 Zurich (Switzerland), Fax: (+41)?446‐331‐235 http://www.seeberger.ethz.ch
Abstract:
Continuous organocatalysis : Fast aldol and Mannich reactions require less catalyst when conducted in a microreactor. A proline tetrazole derivative (5–10 mol %) catalyzes asymmetric aldol reactions between various aromatic aldehydes and ketones in microreactor at 60 °C with reaction times ranging from 10 to 30 min.
