Department of Chemistry, Yale University, P.O. Box 208017, New Haven, CT 06520‐8107 (USA), Fax: (+1)?203‐432‐3221 http://ursula.chem.yale.edu/～hamgrp
Abstract:
Come together : A novel method for assembling monomers and controlling structure of a de novo helix bundle protein is described. A guanine (G)‐rich oligodeoxynucleotide scaffold forms a hydrogen‐bonded DNA quadruplex in the presence of potassium counterions, thereby inducing a helical structure and fourfold stoichiometry in conjugated, amphiphilic peptide sequences. The DNA scaffold shows potential for rapidly assembling designed proteins.
