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Synthesis,Characterization, Cytotoxicity,and Hydrolytic Behavior of C2‐ and C1‐Symmetrical TiIV Complexes of Tetradentate Diamine Bis(Phenolato) Ligands: A New Class of Antitumor Agents
Authors:Dani Peri  Sigalit Meker  Michal Shavit  Edit Y Tshuva Dr
Institution:Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel), Fax: (+972)?2‐658‐4282
Abstract:Carefully design your ligand! A new family of highly cytotoxic TiIV complexes demonstrates strong dependence of activity on the particular ligand employed, in which small structural modifications dramatically affect both hydrolytic behavior and biological activity (see picture). Different structure‐dependence patterns are observed for hydrolysis and cytotoxicity, which are, nonetheless, strongly related.
image

Keywords:antitumor agents  cytotoxicity  hydrolysis  phenolato ligands  titanium
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