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On the Function and Structure of Synthetically Modified Porins |
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| Authors: | Simon Reitz Menekse Cebi Philipp Reiß Gregor Studnik Uwe Linne Ulrich Koert Prof?Dr Lars‐Oliver Essen Prof?Dr |
| Institution: | Fachbereich Chemie, Philipps‐Universit?t Marburg, Hans‐Meerwein‐Strasse, 35032 Marburg (Germany), Fax: (+49)?6421‐282‐5677 |
| Abstract: | The attachment of modulators to a trimeric porin ion channel was investigated (see picture of the trimer with a crown ether modulator (orange)). The interplay of modulator and protein is essential for the conformational heterogeneity of the hybrid channel. Single‐site attachment in large pores is not sufficient to change the electrophysiological characteristics of the pores—such change requires additional noncovalent interactions or second‐site attachments.  |
| Keywords: | crown compounds ion channels native chemical ligation porin structures ion‐current modulators |