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Charge‐Conversional Polyionic Complex Micelles—Efficient Nanocarriers for Protein Delivery into Cytoplasm |
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| Authors: | Yan Lee Dr. Takehiko Ishii Dr. Horacio Cabral Dr. Hyun Jin Kim Ji‐Hun Seo Nobuhiro Nishiyama Dr. Hiroki Oshima Kensuke Osada Dr. Kazunori Kataoka Prof. Dr. |
| Affiliation: | 1. Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7‐3‐1 Hongo, Bunkyo‐ku, Tokyo 113‐0033 (Japan), Fax: (+81)?3‐5841‐7139;2. Department of Bioengineering, The University of Tokyo, 7‐3‐1 Hongo, Bunkyo‐ku, Tokyo 113‐8656 (Japan);3. Department of Materials Engineering, The University of Tokyo, 7‐3‐1 Hongo, Bunkyo‐ku, Tokyo 113‐8656 (Japan);4. Center for Nanobio Integration, The University of Tokyo, 7‐3‐1 Hongo, Bunkyo‐ku, Tokyo 113‐8656 (Japan) |
| Abstract: | Special delivery! Polyionic complex (PIC) micelles that contain the charge‐conversional moieties citaconic amide or cis‐aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross‐linking, and the charge‐conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).  |
| Keywords: | charge conversion cytochromes drug delivery endosomes micelles |