Department of Chemistry, University of York, Heslington, York, YO10 5DD (UK), Fax: (+44)?1904‐432‐516, http://www.york.ac.uk/depts/chem/staff/dks.html
Abstract:
Now you bind it—now you don't! Chemical degradation of a dendritic scaffold allows multivalent interactions with DNA to be “switched off” as the multivalent array of ligands breaks down into smaller fragments, offering an approach by which a molecule can be temporarily endowed with high affinity for a biological target—an important concept in the development of new synthetic systems to intervene in biological pathways.
