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Engineering Bisquinolinium/Thiazole Orange Conjugates for Fluorescent Sensing of G‐Quadruplex DNA |
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| Authors: | Peng Yang Dr. Anne De Cian Marie‐Paule Teulade‐Fichou Dr. Jean‐Louis Mergny Dr. David Monchaud Dr. |
| Affiliation: | 1. Muséum National d'Histoire Naturelle (MNHN), USM 503 INSERM, U565, CNRS, UMR5153, 43 Rue Cuvier, Case postale 26, 75005 Paris (France), Fax: (+33)?1‐40‐79‐37‐05;2. Institut Curie, Section Recherche, CNRS, UMR176, Centre Universitaire Paris XI, Bat. 110, 91405 Orsay (France), Fax: (+33)?1‐69‐07‐53‐81 |
| Abstract: | Lighting up : A G‐quadruplex‐specific fluorescent probe was designed combining the specificity of the pyridodicarboxamide motif for guanine quadruplexes and the fluorescence properties of thiazole orange. While the assembly of the two partners through a flexible linker leads to a nonselective probe, merging them in a single, rigid scaffold leads to a dye that elicits the properties required for G‐quadruplex sensing.  |
| Keywords: | DNA fluorescence probes G‐Quadruplex guanine |