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Multinuclear Non‐Heme Iron Complexes for Double‐Strand DNA Cleavage |
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| Authors: | Rik?P Megens Tieme?A van?den?Berg Dr A?Dowine de?Bruijn Ben?L Feringa Prof?Dr Gerard Roelfes Dr |
| Institution: | Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen (The Netherlands), Fax: (+31)?50‐363‐4296 |
| Abstract: | Bleomycin mimics : Efficient oxidative double‐strand DNA cleavage has been achieved with multinuclear non‐heme iron complexes (see scheme). These complexes therefore represent model compounds that mimic the mode of action of the anti‐tumor drug bleomycin.  |
| Keywords: | artificial nucleases DNA cleavage double‐strand cleavage iron multitopic complexes |