首页 | 本学科首页   官方微博 | 高级检索  
     


De Novo Design of a βαβ Motif
Authors:Huanhuan Liang  Hao Chen Dr.  Keqiang Fan Dr.  Ping Wei Dr.  Xianrong Guo Dr.  Changwen Jin Prof.  Chen Zeng Prof.  Chao Tang Prof.  Luhua Lai Prof.
Affiliation:1. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (China);2. Department of Physics, The George Washington University, Washington, DC 20052 (USA);3. Beijing Nuclear Magnetic Resonance Center, Beijing 100871 (China);4. Departments of Biopharmaceutical Sciences and Biochemistry and Biophysics, University of California, San Francisco, CA 94158 (USA);5. State Key Laboratory for Structural Chemistry of Unstable and Stable Species, BNLMS, College of Chemistry and Molecular Engineering and Center for Theoretical Biology, Peking University, Beijing 100871 (China), Fax: (+86)?10‐6275‐1725, http://mdl.ipc.pku.edu.cn
Abstract:A designer monomeric protein with a βαβ fold—two parallel β strands connected by an α helix (see structure)—was constructed solely from coded amino acids. The high thermal stability of the structure is due to a large extent to tryptophan–tryptophan interactions between the two β strands.
image

Keywords:foldamers  peptides  protein design  tertiary structure  WW interactions
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号