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One‐Pot Formation of Large Macrocycles with Modifiable Peripheries and Internal Cavities |
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| Authors: | Joseph S Ferguson Dr Kazuhiro Yamato Dr Rui Liu Lan He Prof Xiao Cheng Zeng Prof Bing Gong Prof |
| Institution: | 1. Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260 (USA), Fax: (+1)?716‐645‐6963;2. Colleges of Chemistry and Resources Science and Technology, and State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875 (China);3. Department of Chemistry, University of Nebraska‐Lincoln, Lincoln, NE 68588 (USA) |
| Abstract: | The shape of things to come : Aromatic oligohydrazide macrocycles with planar backbones enforced by three‐center hydrogen bonds are formed in high yield from monomeric diacid chlorides and dihydrazides. Macrocycles consisting of six meta‐linked pyridine and benzene residues have an internal cavity of about 10 Å diameter, while those with alternating meta‐ and para‐linked benzene residues are larger and contain multiple convergent sites (see picture).  |
| Keywords: | foldamers hydrogen bonds macrocycles synthesis design |