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Mechanism‐Guided Development of VO(salen)X Complexes as Catalysts for the Asymmetric Synthesis of Cyanohydrin Trimethylsilyl Ethers |
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| Authors: | Yuri N Belokon Prof William Clegg Prof Ross W Harrington Dr Victor I Maleev Dr Michael North Prof Marta Omedes Pujol Dmitry L Usanov Carl Young |
| Institution: | 1. A.?N. Nesmeyanov Institute of Organo‐Element Compounds, Russian Academy of Sciences, 119991, Moscow, Vavilov 28 (Russian Federation);2. School of Chemistry and University Research Centre in Catalysis and Intensified Processing, Newcastle University, Bedson Building, Newcastle upon Tyne, NE1 7RU (UK), Fax: (+44)?870‐131‐3783 |
| Abstract: | Catalyze this! Detailed study of the mechanism of asymmetric cyanohydrin synthesis catalyzed by VO(salen)X complexes (see figure) led to the development of VO(salen)NCS, as the most active vanadium‐based catalyst yet developed for this reaction.  |
| Keywords: | aldehydes asymmetric catalysis cyanides reaction mechanisms vanadium |