Department of Chemistry, Wayne State University, Detroit, MI 48236 (USA), Fax: (+1)?313‐577‐8822
Abstract:
A stereoselective synthesis of cyathin A3 and cyathin B2 has been achieved by a Prins‐type reaction of a cycloalkenyl cyclopropanol. Particularly noteworthy is the use of a spirocyclobutanone moiety as a convenient scaffold for an efficient ring‐closing metathesis to stereoselectively construct a suitably functionalized seven‐membered ring (see scheme).
