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Synthesis of Stable Aminoacyl‐tRNA Analogues Containing Triazole as a Bioisoster of Esters |
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| Authors: | Maryline Chemama Matthieu Fonvielle Dr. Michel Arthur Dr. Jean‐Marc Valéry Prof. Mélanie Etheve‐Quelquejeu Dr. |
| Affiliation: | 1. UMR 7613, Synthèse, Structure et Fonction de Molécules Bioactives, Université Pierre et Marie Curie, 4 place Jussieu, case 179, 75?252 Paris Cedex (France), Fax: (+33)?01?44?27?55?13;2. Centre de Recherche des Cordeliers, LRMA, Equipe 12, INSERM, U872, 75006 Paris (France);3. Université Pierre et Marie Curie, Paris 6, UMR S 872, 75006 Paris (France);4. Université Paris Descartes, UMR S 872, 75006 Paris (France) |
| Abstract: | Stable analogues : An effective synthetic route involving cycloaddition between alkynes and azidonucleosides to afford a new class of stable aminoacyl‐tRNA analogues such as depicted is presented. Biological evaluation showed that theses new compounds act as potent inhibitors of FemXWv aminoacyl transferase, a novel drug target.  |
| Keywords: | aminoacyl‐tRNA click chemistry dinucleotides inhibitors triazoles |