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Selective Identification of Cooperatively Binding Fragments in a High‐Throughput Ligation Assay Enables Development of a Picomolar Caspase‐3 Inhibitor
Authors:Marco F. Schmidt Dr.  Adeeb El‐Dahshan Dr.  Sandro Keller Dr.  Jörg Rademann Prof. Dr.
Affiliation:1. Leibniz Institute of Molecular Pharmacology (FMP), Robert‐R?ssle‐Strasse 10, 13125 Berlin (Germany), Fax: (+49)?30‐9406‐2901;2. Institute of Chemistry and Biochemistry, Free University Berlin, Takustrasse 3, 14195 Berlin (Germany)
Abstract:
Keywords:caspase‐3  drug discovery  fluorescence polarization  high‐throughput screening  protease inhibitors
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